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In this cohort, 5 of those receiving an anti-TNF agent and 7 of those undergoing immunomodulators were classified as frail in the 2 years prior to treatment. It was also determined that they were generally older and had comorbidities. A higher proportion of them developed infections 19 after anti-TNF and 17 after immunomodulators, compared to those who were physically fit. The increased risk in frail people remained after adjusting for confounding factors. Located northeast of Nairobi, the Mathare slum serves as a refuge for a population estimated between 300,000 and 450,000 people.

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The percentage of subjects who had a reduction in transfusion burden of at least 33 from baseline during weeks 13 to 24, plus a decrease of at least two units of red blood cells in this 12-week interval, was significantly higher with luspatercept than in controls 21. 4 versus 4. 5, P 0. 001. During any 12-week interval, the ometab of people who had a reduction in transfusion burden of at least 33 was higher in those treated with the drug than in placebo 70. 5 versus 29. 5, as well as the percentage of those who had a decrease of at least 50 40. 2 versus 6. The mean difference in serum ferritin levels between groups at week 48 was -348 Оg per liter 95 CI, -517 to -179 in favor of luspatercept. The adverse events of transient bone pain, arthralgia, dizziness, hypertension, and hyperuricemia were more common with the drug than with placebo.

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