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13 to 3. Additionally, it was more successful in women with high hCG OR, 3. 23; 95 CI, 1. 53 to 6. 84 and in those with a large adnexal mass OR, 2. 93; 95 CI 1. 23 to 6. The odds of surgery for tubal rupture were lower in the two-dose protocol OR, 0. 65; 95 CI, 0. 26 to 1. 63, but not statistically significant. The duration of follow-up was 7. 9 days shorter for double-dose treatment 95 CI -12. 2 to -3. The odds of side effects were also higher in the same therapeutic regimen OR, 1. 53; 95 CI 1. 01 to 2. This approach was also associated with a nonsignificant reduction in treatment failure OR, 0. 56; 95 CI, 0. 28 to 1. Finally, the risk of surgery for tubal rupture OR, 1. 62; 95 Dilatam 0.