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The objective of the study was to evaluate the associations between exposure to fetal folic acid, cortical maturation and psychiatric risk in young people. A retrospective observational cohort study was conducted at Massachusetts General Hospital involving 292 youth ages 8 to 18 years born between January 1993 and December 2001 including folic acid fortification deployment В3. 5 years. Normative clinical MRI results were obtained, divided into 3 age-matched groups based on date of birth and related level of prenatal exposure to folic acid fortification none, partial, or complete. MRI was performed between January 2005 and March 2015. Additionally, for replication, clinical extension and specificity, two independent, observational and community-based cohorts were studied Philadelphia Neurodevelopmental Cohort PNC and National Institutes of Health Magnetic Resonance Imaging Study of Normal Brain Development NIH that included 1,078 young people aged 8 to 18 years born during PNC, 1992 - 2003 or before NIH, 1983 - 1995 the implementation of the fortification.
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