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5 of 206 women in UF-1 and 76. 5 of 189 in UF-2 who received elagolix plus hormone replacement therapy, compared with 8. 7 of 102 women and 10 of 94 women, respectively, in the placebo group P0. 001 for both trials. Among women receiving elagolix alone, the primary endpoint was met in 84. 1 of 104 women in UF-1 and 77 of 95 women in UF-2.