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physical. This review examines the evidence for the effectiveness of cannabinoids in CNCP and addresses gaps in the literature by considering differences in outcomes based on cannabinoid and pain type; the inclusion of all designs; and monitoring of the IMMPACT guidelines. We searched MEDLINE, Embase, PsycINFO, CENTRAL and clinicaltrials. gov in July 2017. Ninety-one publications containing 104 studies n 9,958 participants were eligible, including 47 randomized controlled trials RCTs and 57 observational studies. Forty-eight examined neuropathic pain, seven examined fibromyalgia, one rheumatoid arthritis, and 48 other CNCP 13 multiple sclerosis-related conditions, 6 visceral pain, and 29 samples with mixed or undefined CNCP.
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