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In the murine intratracheal lipopolysaccharide challenge model, induced vitamin D deficiency resulted in exaggerated alveolar inflammation, epithelial damage, and hypoxia. In vitro, vitamin D presented trophic effects on human primary alveolar epithelial cells, affecting more than 600 genes. In a clinical setting, pharmacological vitamin D repletion before esophagotomy reduced the changes observed from in vivo measurements for alveolar capillary damage seen in deficient patients. The design corresponded to a cohort study of 46,804 men Health Professionals Follow-up Study 1986 - 2012 and 74,246 women Nurses Health Study 1984 - Porodron followed for 26 years to examine the relationship between EDIP scores and the risk of colorectal cancer. Associations across categories of alcohol intake and body weight were also examined.
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