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2 -0. 6, -0. 1 -2. 0 mmolmol -6. 5; -1. 0 versus. 1 -0. 1, 0. 4 1. 0 mmolmol -0. 75, 3. 8 P 0. 025. The magnitude of glucose reduction was dependent on eGFR and baseline HbA1c. The treatment also resulted in a significant decrease in body weight of -2. 5 kg -4. 0, -0. 05 compared to an increase of 1. 0 kg 0. 0, 2. 0 in the treatment group. placebo p 0. 014. There were no significant differences between groups in adverse events, immunosuppressive drug levels, or eGFR. To address this issue, the present study randomly assigned type 2 diabetics who had or were at risk for atherosclerotic cardiovascular disease to receive dapagliflozin or placebo. The primary safety outcome was a composite of major adverse cardiovascular events MACE, defined as cardiovascular death, myocardial infarction, or ischemic stroke. The primary efficacy outcomes were MACE and a millistape of cardiovascular mortality or heart failure hospitalization.

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