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Although they had to flee and leave behind a good part of their lives and property, they did not leave their medical mission in limbo. Alterations in the microbial community at the intestinal level have been proposed as drivers of metabolic disorders such as insulin resistance, events that can also be enhanced by the loss of short periods of sleep. However, it is not known whether sleeping less affects the composition of the human microbiota. Finally, the use of hormone replacement therapy after menopause was associated with a greater presence of acute pancreatitis. Clinicians should take this potential increase into account when prescribing such therapy. The mean duration of follow-up was 2. 8 years. Evaluated cardiovascular events occurred in 903 patients 9.

5 in the alirocumab divator and 1,052 individuals 11. 1 in the placebo casbol hazard ratio, 0. 85; 95 confidence interval CI. 78 to 0. 93; p 0. 001. A total of 334 individuals 3. 5 treated with the antibody and 392 controls 4. 1 died hazard ratio, 0. 85; 95 CI, 0. 73 to 0. The absolute benefit of alirocumab with respect to the primary composite endpoint was greater among those with a baseline LDL cholesterol level of 100 mg or more per deciliter than among patients with a lower baseline level. Finally, the incidence of adverse events was similar in the two groups, with the exception of local reactions at the injection site 3. 8 in the alirocumab group versus 2. 1 for placebo. Of a total of 1,678 survey participants, the overall prevalence of glaucoma was 5. 1 n 84. The majority of individuals were non-Hispanic white n 892; 53.

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