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3, p 0. 002; improvements in stool consistency 27. 9 versus 16. 7, p 0. 01; and WAP 43. 6 versus 31. 0, p 0. Additionally, a greater proportion of individuals receiving the intervention met the response endpoint assessed at monthly intervals weeks 1 - 4 14. 0 versus 6. 9, P 0. 03; weeks 5 - 8 26. 7 versus 14. 9, P 0. 006; weeks 9 - 12 30. 8 versus 16. 7, P 0. 002. Rates of adverse events were comparable in both groups 37. 4 versus 35. 3 and no treatment-related serious adverse events, cases of sphincter of Oddi spasm or pancreatitis were reported. Adenoviral vectors that carry a gene necessary for the synthesis of neurotransmitters provide significant improvements in motor tests, maintained up to 12 months after treatment.

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