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Pharmacological inhibitors of proprotein convertase subtilisin-kexin type 9 PCSK9 are being evaluated in clinical trials for the treatment of cardiovascular diseases. However, the effects on the risk of these events or diabetes after the reduction in LDL cholesterol levels promoted by PCSK9 inhibition are unknown. David A. Merrill and colleagues Semel Institute for Neuroscience Human Behavior, Los Angeles, United States recruited volunteers N 44; mean age 62. 6 В 10. 7 years with subjective memory impairment N 24 or mild cognitive impairment MCI; N 20. The levels of physical activity and the degree of adherence to the diet Mediterranean type were evaluated through self-reports.
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