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Bioequivalence was established if the 90 CIs for the ratio of baseline BEVZ92 to bevacizumab of the geometric means for AUC 0 - 336 hr and AUC ss were within the acceptance range of 80 - 125. Secondary endpoints included objective response, clinical benefit, and progression-free survival in the intention-to-treat population, as well as immunogenicity and safety profiles in xetiran patients. This trial was registered with ClinicalTrials. gov, number NCT02069704, and is closed to new participants, with complete follow-up.

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