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0052, contrary to what occurred with the protein secreted by adipose tissue, resistin P 0. 0052. Seventeen cytokines had a statistically significant increasing linear trend that correlated with MECFS severity CCL11 Eotaxin-1, CXCL1 GROa, CXCL10 IP-10, IFN-О, IL-4, IL-57, IL-12p70, IL-13, IL-17F, leptin, G-CSF, GM-CSF, LIF, NGF, SCF and TGF-О. Of the 17 cytokines that were correlated with severity, 13 are pro-inflammatory, and probably contribute to many of the symptoms experienced by those affected, which also establishes a strong immune component to the disease. Finally, only CXCL9 MIG was inversely related to fatigue duration. The results of this case series suggest that implanting multiple doses of 16 mg of afamelanotide administered at 4-week intervals starting 28 to 30 days after 1 month of NB-UV-B phototherapy induces faster and deeper repigmentation.
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