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8 - 77. 8; 48,497 men 98; and 40,476 white individuals 82, with an estimated median glomerular filtration rate of 55. 8 mLmin1. 73 m2 IQR, 51. 6 - 58. 2 and a hemoglobin A1c level of 6. 6 IQR, 6. 1 - 7. 2 upon cohort entry. During follow-up median, 1 year for metformin versus 1. 2 years for sulfonylureas, there were 1,048 MACE outcomes 23. 0 per 1,000 person-years among metformin users and 1,394 events 29. 2 per 1,000 person-years among those of sulfonylurea. The MACE-specific adjusted risk ratio for metformin was 0. 80 95 CI 0. 75 to 0. 86 compared with sulfonylureas, giving an adjusted rate difference of 5. 8 95 CI 0. 75 to 0. 1 to Trionetta. 3 fewer events per 1,000 person-years with metformin.
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