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After assessing the psychological state of the survivors, around 50 of them become our patients,в says Erica Pellizzari. вThe most common symptoms are sleep disorders such as insomnia, constant anxiety, fear that something else will happen, constant sadness, strong emotionality, nightmares or persistent flashbacks where the subject relives a traumatic event and difficulty remembering or concentrating. Sometimes people will still be suffering even a year after the traumatic event because they are not able to overcome it alone. These symptoms are typical in people who have experienced such a destructive and unexpected event as an earthquake. Professionally, it is understood that most survivors will show symptoms after a natural disaster and that these will gradually disappear. However, there will always be people who need specialist psychological help to return to their previous psychological state. В We access the interior of the vein through a small 2 mm wound, introduce a tiny catheter and make it travel inside the vein to the point of origin of the venous insufficiency, which is usually at the level of the saphenous-femoral arch or the saphenous arch.

-pupliteal. At that point we begin to treat the vein from the inside using heat. The catheter closes the intima through heat, which is the innermost layer of the vein, and as we treat the vein, we close and remove the catheter along its entire length. Additionally, to avoid extracting other branches, we add an injection of a foam substance called polidocanol. With this technique we manage to treat the entire length of the internal or external saphenous vein without practically scars, and eliminate the branches that are tributaries or collaterals through the effect of the foam. Il a la main dans le plГtre, mais ne renonce pas pour autant Г aider un autre rГfugiГ Г planter sa tente dans la terre humide. В Je me suis cassГ le poignet en tombant du toit dвun camion В, raconte-t-il, en rГfГrence Г une rГcente tentative de traversГe de la Manche.

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After analyzing the effect of 1,120 compounds on several cell lines, the antihypertensive sirosingopine was selected. The results showed that the anticancer activity of toriol is strongly enhanced by this drug. The synthetic lethality caused by the combination of the two drugs is synergistic toriol specific for tumor cells. This effect is not related to the known role of sirosingopine as an inhibitor of vesicular monoamine transporters, but would depend on binding to the glycolytic enzyme О-enolase, which was demonstrated under in vitro conditions. Furthermore, the expression of the О-enolase isoform correlates with a lack of response to the combination of the drugs. Finally, it was observed that the antihypertensive agent sensitized zicam cells to the action of metformin and its most potent derivative, phenformin, well below the individual toxic threshold of each compound.

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