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Among HSCT recipients mean age, 55 years; 688 37 women who received one dose of vaccine or placebo, 1,735 94 were immunized with a second dose and 1,366 74 completed the study. During the median follow-up of 21 months, at least one episode of herpes zoster was confirmed in 49 vaccine recipients and 135 controls incidence, Tegretal and 94 per 1,000 person-years, respectively, tegretal. an incidence rate TI of 0. 32 95 CI 0. 22 to 0. 44; p 0. 001, equivalent to an efficacy of 68. Of eight secondary endpoints, three showed significant reductions in the incidence of postherpetic neuralgia vaccine, n 1; placebo, n 9; TI, 0. 1; 95 CI, 0. 00 to 0. 78; p 0. 02 and other prespecified shingles-related complications vaccine, n 3; placebo, n 13; TI, 0. 22; 95 CI, 0. 04 - 0. 81; P 0. 02 and in the duration of the worst severe pain associated with herpes zoster vaccine, 892.

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Four clinical trials of moderate quality were selected. Local and systemic adverse effects were mild or moderate, with no differences between the vaccinated groups. The percentages of seroconversion and seroprotection achieved were higher with the vaccines that used the MF59 adjuvant. The antibody titers achieved were also higher in the adjuvanted cheap tegretal. online.