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During the hostilities, the Ministry of Health hospital, supported by MSF, was caught in crossfire, forcing patients and medical staff to flee. Following this incident, some 7,000 newly displaced people gathered in two camps near the village of Shangil Tobaya. From May 2012 to May 2017, a total of 61 patients were enrolled and received one dose of PVSRIPO. Dose level -1 5. 0Г-10e7 TCID50 was identified as the phase 2 dose. A dose-limiting toxic effect was observed. One patient administered dose level 5 10e10 TCID50 had a grade 4 intracranial hemorrhage immediately after catheter removal. To mitigate locoregional inflammation of the infused tumor with long-term use of glucocorticoids, dose level 5 was reduced to reach the phase 2 dose. In the dose expansion phase, 19 of individuals had an adverse event related to PVSRIPO grade 3 or higher.
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