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Pregnancy involves surges in hormones and biological adaptations. However, the effects of pregnancy on the human brain are practically unknown. Diona Damian and her team at the University of Sydney, Australia, conducted a phase 3, double-blind, controlled trial, where they randomly assigned 386 participants in a 11 ratio to receive 500 mg of nicotinamide twice daily. or placebo for 12 months. The people had had at least two types of nonmelanoma skin cancer 5 years before the study and were evaluated by dermatologists at 3-month intervals for 18 months. The primary criterion for determining the end point was the number of new cases during the 12-month intervention period. Secondary objectives included the number of new squamous cell and basal cell carcinomas and the number of actinic keratosis during the same time, the number of nonmelanoma skin cancer in the 6-month postintervention period, and safety.

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005, received fewer transfusions 2 versus 3. 5, P 0. 01, and achieved full enteral feeding sooner 40 versus 46 days.P 0. Intact survival at school age was significantly increased in the 42-day group 75 compared with the 9-day treatment 34, P 0. 005.