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Neurologists at the Royal North Shore Hospital, St. Leonards, Australia, prospectively determined the reliability and validity of fibroblast growth factor 21 FGF-21 as a biomarker for mitochondrial pathology in a cross-sectional population of adults. 140 subjects were considered, including 54 with mitochondrial disease, 20 with non-mitochondrial neuromuscular disease and 66 controls, between November 2011 and October 2012. FGF-21 concentrations were compared with classic markers, such as creatine kinase, lactate, pyruvate and the lactatepyruvate ratio. Using statistical analyses, the sensitivity, risk R, and overall reliability of FGF-21 as a marker of mitochondrial disease were determined. In summary, treatment with tralokinumab is associated with early and sustained improvements in atopic dermatitis symptoms and with an acceptable safety and tolerability profile, providing evidence to focus attention on IL-13 in patients suffering from this condition.
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