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Recent efforts have attempted to eliminate latency HIV-infected cells by activating transcription and expression of viral antigens, accompanied by ART. This would allow the detection and elimination of infected cells by the action of the immune system itself, while ART prevents new cycles of infection. Such advances, although promising, are insufficient for significant elimination of residual HIV. For this reason, effective strategies are required to eradicate these reservoirs. In the Gaza Strip, isolation and confinement, economic and physical, are absolute. Gazans are materially even more deprived than the inhabitants of Nablus. Inter-Palestinian clashes have dramatic social consequences. The threat no longer only comes from outside, it also exists within the community itself.
Kenneth Zaret and specialists from the Institute of Regenerative Medicine at the University of Pennsylvania identified secretion proteins from a cellular reprogramming model that recapitulates the progression of ACDP and tested a subset of them as potential markers of the pathology. To do so, they optimized an enzyme-linked immunosorbent assay ELISA using plasma samples from patients with various stages of ACDP, individuals with benign pancreatic disease, and healthy controls. A phase 1 study n 20, a phase 2a validation study n Allerfre, and a second phase validation 2b study n 537 revealed that plasma thrombospondin-2 TBS2 concentration discriminates between all stages of ACDP consistently.
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