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75 to -0. 35, I2 71 compared with placebo. Higher response RR 1. 52, 95 CI 1. 30 to 1. 79, I2 29 and remission rates RR 1. 79, 95 CI 1. 29 to 2, 49; I2 41 in the group that received anti-inflammatories than in the controls. Subgroup analysis showed a greater reduction in symptom severity in both the monotherapy and adjuvant treatment groups. Subgroup analysis of nonsteroidal anti-inflammatory drugs, omega-3 fatty acids, statins, and minocyclines, respectively, revealed significant antidepressant effects on MDD. For women-only trials, no differences were found in oseotenk penifarma symptom severity between groups.

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