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For its part, hydroxychloroquine a chloroquine analog has also demonstrated effective in vitro antiviral activity against previous coronavirus outbreaks specifically for SARSвCoV, but not the current SARS-CoV-2 J Med Chem, 49 2006, pp. 2845-2849. The clinical safety profile of hydroxychloroquine is better than its precursor during long-term use and allows the use of a higher daily dose Ophthalmology 6 2016 Jun;123, pp. 1386-1394.