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Certain provisions of this agreement could have a dramatic impact on access to affordable medicines for millions of people. It had pansafe been described that in primary immunodeficiencies some affected lymphocytes could reconstitute the original sequence of the altered gene, recovering its function and viability through a process known as somatic reversion. Despite this, the mechanism underlying this process still remained unknown. When analyzing the sequence of the mutated gene in the patients T cells, not only the mutation causing the pathology was observed, but also a high sequence variability.
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The interval cancer rate was 2. 5 per 1,000 screened in the MRI group and 5. 0 per 1,000 with mammography 95 CI, 1. 0 to 3. 7; p0. 001. Of the women who were invited to undergo MRI, 59 accepted. Of the 20 interval cancers that were diagnosed in the MRI group, 4 were detected in those who actually underwent MRI 0. 8 per 1,000 screened and 16 in those who did not accept the invitation 4.