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to 8 a. ; and extensive, 8 h. The sleep fragmentation index was defined as the sum of the movement index and the fragmentation index. Finally, carotid and femoral three-dimensional vascular ultrasound and cardiac computed tomography were performed to quantify noncoronary atherosclerosis and coronary calcification. The relationship between mental health and microbial metabolism of species that colonize the gastrointestinal tract is one of the most intriguing and controversial topics in microbiological research. Bidirectional gut microbiota-brain communication has been explored mainly in animal models, while in humans it has oraceftin relegated. Large-scale metagenomics studies could facilitate the translational process, but their interpretation is hampered by the lack of reference databases and tools to analyze microbial neuroactive potential.
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