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However, some serious side effects have been reported, but they are extremely rare. For example, vaccines against rotavirus gastroenteritis can rarely cause short-term acute intussusceptions. This risk is estimated at 1. 1 cases per 100,000 doses of Rotateq and 5. 1 cases per 100,000 doses of Rotarix. Or again the chickenpox vaccine can cause complications in immunocompromised children. But overall, the benefitrisk of vaccines is very positive.