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immunized. Changes in antibody titers were not associated with the time between vaccination and surgery, age or weight at surgery, nor with blood products administered, number of previous doses, time in the BCP or diagnosis of heterotaxy for the most vaccines. 358 data sets were identified that contributed information to the analysis, representing a total of 56,044 adults in 63 countries. Pretreatment NNRTI resistance prevalence estimates in 2016 were 11. 0 7. 5 - 15. 9 in Southern Africa, 10. 1 5. 1 - 19. 4 in Eastern Africa, 7. 2 2. 9 - 16. 5 in West and Central Africa, and 9. 4 6. 6 - 13. 2 in Latin America and the Caribbean. There were substantial increases in NNRTI resistance before treatment norfloxacina year in all regions. Annual increases in the odds of pre-treatment resistance were 23 95 CI 16 - 29 in Southern Africa, 17 5 - 30 in Eastern Africa, 17 6 - 29 in Africa western and central, 11 5 - 18 in Latin America and the Caribbean and 11 2 - 20 in Asia.
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