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At the end of 2008, UNICEF and the World Food Program WFP announced that they would distribute Plumpydoz in Somalia, Burkina Faso, Afghanistan and Madagascar. Of the 255 patients who underwent randomization, 129 were assigned to ibudilast and 126 to placebo. A total of 53 of participants in the ibudilast group and 52 of those taking placebo had primary progressive disease. The rest had the secondary progressive form. The rate of change in brain parenchymal fraction was -0. 0010 per year with ibudilast and -0. 0019 per year with placebo difference, 0. 0009; 95 CI, 0. 00004 to 0. 0017; P 0. 04, representing approximately 2.

5 mL less brain tissue loss with ibudilast over a 96-week period. Adverse events with the drug included gastrointestinal symptoms, headache, and depression. Betalotio winthrop total of 89 3,741 of 4,203 of the participants gave their consent for the study of cognitive functions and 93. 6 3,501 of 3,741 were finally subjected to the analysis. The average SD age of the participants was 72. 7 7. 7 years and 57. 5 were women. The results showed that there were no statistically significant differences in change scores for participants randomly assigned to receive supplements versus those who did not receive supplements. The annual change in composite cognitive function score was -0.

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