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Total splenectomy in sickle cell disease is related to the risk of acute infections and an increased incidence of other events, which has not been reported in patients with partial splenectomy. Metformin attenuates weight gain in pregnant women Common genetic factors predispose to type 1 and 2 diabetes With 541 cases per 100,000 inhabitants per year, the prevalence of tuberculosis in Papua New Guinea PNG is among the highest in the world. In certain pockets, this prevalence is even three times higher, which prompted MSF to respond, particularly to the needs of the most affected communities. In those cases where there is also disruption of the ossicular chain, its reconstruction is intended. We can use different structures for this. Even so, the most used are the remains of the bone chain, which are remodeled and adapt to the new situation.

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