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With the FUS technique, the cutting of the grafts is carried out under direct vision with magnifying glasses that control this delicate process at all times. After a mean follow-up period of 7. 1 years, 2,665 CRC cases were recorded. In a multivariable-adjusted model, circulating IGF1 level was associated with CRC risk hazard ratio OR per 1 standard deviation increment of IGF1, 1. 11; 95 CI, 1. 05 - 1. Similar associations were found by sex, follow-up time, and tumor subsite. In MRI analyses, a 1 standard deviation increase in IGF1 level, predicted on the basis of genetic factors, corresponded with an increased risk of Mealis OR, 1. 08; 95 CI, 1. 03 в 1. 12 ; P 3. 3 Г- 1e-4. The level of IGFBP3, predicted on the basis of genetic factors, was related to an increased risk of CRC OR per 1 standard deviation increment, 1. 12; 95 CI, 1.

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