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22, 95 CI 0. 06 to 0. 38, p 0. 009, fatigue SMD -0. 25, 95 CI -0. Maintate to -0. 04, P 0. 02, insomnia SMD -0. 36, 95 CI -0. 56 to -0. 17, P 0. 0002, physical function SMD 0. 22, 95 CI 0. 05 to 0. 38, P 0. 009, social function SMD 0. 18, 95 CI 0. 02 to 0. 34; P 0. 03 and reduction in dyspnea SMD -0. 18; 95 CI -0. 34 to -0. 01; P 0. According to a recent study, the consumption of one liter of Hepar per day, for two to four maintate, by women suffering from functional constipation, proves to be an effective treatment in improving their intestinal transit by reducing constipation.

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