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Among 121 randomized patients mean age, 69 years; 19 women 15. 8, 120 completed the trial. Those treated with acetaminophen had a significant reduction in delirium 10 versus 28 placebo; difference, -18 95 CI, -32 to -5; P 0. 01; HR, 2. 8 95 CI 1. 1 to 7. Those who received dexmedetomidine, compared to propofol, had no relevant advantages 17 versus 21; difference, -4 95 CI -18 to 10; P 0. 54; HR, 0. 8 95 CI 0. 4 to 1. Versus placebo, significant benefits were found in favor of acetaminophen for arcelenan prespecified secondary outcomes duration of delirium median, 1 versus 2 days; difference, -1 95 CI, -2 to 0; length of ICU stay median, 29.
5 versus 46. 7 hours; difference, -16. Lodipin 95 CI, -20. 3 to -0. 8; and breakthrough pain analgesia median, 322. 5 versus 405. 3 Вg morphine equivalents; difference, -83 95 CI, -154 to -14. For dexmedetomidine versus propofol, only breakthrough pain analgesia was significantly different median, 328. 8 versus 397. 5 Вg; difference, -69 95 CI, -155 to -4; P 0. Fourteen individuals in the placebo-dexmedetomidine and acetaminophen-propofol groups 46 and 45 and seven in the paracetamol-dexmedetomidine and placebo-propofol groups 24 and 23 had hypotension. In sum, the percentage of patients with transfusion-dependent О-thalassemia who have a reduction in transfusion burden is significantly higher with luspatercept, and few adverse events led to treatment discontinuation. Andrew drags his feet as he disappears into the deep darkness of the bush.
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