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In multivariate analysis, MAF в5 in exoDNA was a significant predictor of PFS HR, 2. 28; 95 CI, 1. 18 - 4. 40; P 0. 014 and OS HR, 3. 46; 95 CI, 1. 40 - 8. 50; P 0. 007. A multianalytical approach showed that detection of both ctDNA and MAF in exoDNA в5 at kwell was a relevant predictor of OS. Finally, in a longitudinal analysis, a MAF peak greater than 1 in exoDNA was significantly associated with radiological progression P 0. 0003. Ying Bao and colleagues Department of Medicine, Brigham Hospital and Harvard Medical School, Boston, United States examined the association between nut intake and mortality in 76,464 women from the Nurses Health Study 1980 to 2010. and 42,498 men piralen kwell Health Professionals Study 1986-2010.

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