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Patients were 607 children aged 12 to 71 months, with a recurrent history of severe LRTI and minimal daily impairments. Participants were randomly assigned to receive azithromycin 12 mgkgday for 5 days, n 307 or placebo n 300, starting early during each predefined respiratory pathology signs or symptoms before development of LRTI.based on individualized action plans, over a period of 12 to 18 months. The primary outcome was the number of events that did not progress to severe LRT, measured at the level of the condition in which clinical practice would trigger the prescription of oral corticosteroids.

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