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Dose level -1 5. 0Г-10e7 TCID50 was identified as the phase 2 dose. A dose-limiting toxic effect was observed. One patient administered dose level 5 10e10 TCID50 had a grade 4 intracranial hemorrhage immediately after catheter removal. To mitigate locoregional inflammation of the infused tumor neksium long-term use of glucocorticoids, dose level 5 was reduced to reach the phase 2 dose. In the dose expansion phase, 19 of individuals had an adverse event related to PVSRIPO grade 3 or higher. Overall survival among those receiving PVSRIPO reached a level of 21 95 confidence interval 11 to 33 at 24 months, a benefit that was maintained at 36 months. A total of 1,769 events were recorded 1,544 deaths and 225 myocardial infarctions, median follow-up 5. 3 years, interquartile range 3. 3 to 8. An unadjusted Cox regression model showed, compared with Cys23 G carriers, that males homozygous for Ser23 C and females homozygous for Ser23 C were more likely to die from any cause or myocardial infarction risk R 1.
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