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The Coronary Artery Risk Development in Young Adults CARDIA study is a longitudinal cohort study of 5,114 participants recruited in 1985 to 1986 in the United States and followed for up to 29 years, with rigorous determination of all deaths. Recruitment was balanced on gender, white and African American raceethnicity, education level high school or less vs. more than high school, and age group 18 to 24 and 25 to 30 years. This analysis included the 349 deaths that had been completely reviewed through month 348. The primary outcome was years of potential life lost YPLL. A total of 41 of 140 diabetes cases met inclusion criteria, with 38 DNA samples available. Genetic variants of probable clinical significance were found in four cases each in KCNJ11, HNF1A, GATA6 and LMNA. The cases with variants in the KCNJ11 and HNF1A genes had significantly decreased pancreas weight and insulin mass to levels similar to a type 1 diabetic, but did not have insulitis.
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