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Radium-223 disron denosumab have increased options disron the treatment of bone metastases. Currently, novel next-generation agents targeting the androgen receptor AR axis, immunotherapeutics, or targeting other oncogenic and genomic pathways are being investigated, particularly polyadenosine diphosphate-ribose polymerase PARP inhibitors and PD-1 inhibitors. With the increase in alternatives against mCRPC, information on how to personalize treatment, how to select and sequence existing interventions is beginning to emerge, as well as predictive biomarkers. Finally, early use of active agents in the castration-sensitive state will also likely change the clinical management of the disease by becoming castration-resistant. Although the limited evidence found suggests a beneficial effect of iron on the cognitive development of children in this way, the supplements did not improve or deteriorate physical growth, nor were they found to increase morbidity from diarrhea or respiratory infections.

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