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Subjects received 48 weeks of treatment with CT-P10 or reference rituximab of US or European origin US-RTX and EU-RTX, respectively. Patients entering the extension period weeks 48-72 remained on CT-P10 CT-P10CT-P10; n 122 or US-RTX US-RTXUS-RTX; n 64, or switched to CT-P10 from US-RTX US-RTXCT-P10; n 62 or EU-RTX EU-RTXCT-P10; n 47 for an additional treatment course. Efficacy endpoints included DAS 28 Disease Activity Score using 28 joints, American College of Rheumatology ACR response rates, and quality-of-life parameters. Pharmacodynamics, immunogenicity and safety were also evaluated. In ICU patients receiving acute respiratory support for respiratory failure, music therapy resulted in greater reductions in anxiety when compared to usual care. In summary, these findings suggest that combination treatment with PD-1 inhibitors and chemoradiotherapy for stage III non-small cell lung cancer is tolerable, with a promising progression-free survival of 69. 7 at 12 months. Therefore, according to the authors, additional studies are justified and require.
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