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1371journal. puts. 0133398. Additionally, various studies have tried to identify the negative effects of these modifications on the muscles, bones, blood circulation and even the brain doi 10. 3389fnbeh. 2015. 00124. To evaluate the safety and effectiveness of IFX for the treatment of patients with Kawasaki disease KD, Hiroshi Masuda and colleagues from multiple university medical centers in Japan conducted a nationwide survey of 274 Japanese institutions that explored how IFX was used for the treatment of KD. Patient sex, age, treatment course, blood test results before and after IFX therapy, coronary artery lesions CAL, and adverse events AEs were also evaluated.