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In vivo, even a small expression of apoE in macrophages and monocytes of apoE mice led to increased levels of miR-146a, and inhibited proinflammatory macrophage responses, Ly-6C monocytosis, and atherosclerosis in hyperlipidemia. Accordingly, cellular enrichment of miR-146a through systemic administration of miR-146a mimetics in ApoE - LDLR - and LDLR - mice attenuated monocytemacrophage activation and atherosclerosis in the absence of a reduction in plasma lipids. In sum, these findings suggest that single CAR T cell progeny induces leukemia remission and that TET2 modification may be useful for improving immunotherapies. Another common condition is suppurations otorrhea, which usually occur when the eardrum is perforated and infected, either because water has entered the ear or because of a cold. вOn other occasions в explains the doctor в they are caused by the so-called cholesteatoma, a benign ear tumor, but which is very aggressive and destroys the bone.
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