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They note, however, that the mortality rate has fallen, compared to a previous survey carried out in the 1990s in eight European countries, thanks to a reduction in mortality linked to HIV infections and overdoses. Furthermore, the French Observatory for Drugs and Drug Addiction OFDT indicates having recorded 34 new substances in circulation in 2014 versus 37 in 2013; this is the first time since 2000 that the number of identifications has not increased. In Europe, 81 new synthetic products were identified in 2013, a figure that is constantly increasing. In conclusion, lower testosterone levels are able to predict rheumatoid arthritis with negative rheumatoid factor, suggesting that hormonal changes precede the onset of the disease and affect its phenotype.

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