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17,160 patients were evaluated, including 10,186 without atherosclerotic cardiovascular disease, cerebramed were followed for a median of 4. 2 years. In the primary safety outcome analysis, dapagliflozin met the prespecified criterion for noninferiority versus placebo with respect to MACE upper limit of the 95 confidence interval CI, 1. 3; P 0. 001 for non-inferiority. In the two primary efficacy analyses, the drug did not result in a lower rate of MACE 8. 8 in the dapagliflozin group and 9. 4 in the placebo group; hazard ratio HR, 0. 93; CI 95 0. 84 to 1. 03; P 0. 17 but did produce a lower rate of cardiovascular death or hospitalization for heart failure 4. 9 versus 5. 8; RR, 0. 83; CI 95 0. 73 to 0. 95; p 0. 005, which reflected a lower rate of hospitalization for this last condition RR, 0. 73; 95 CI 0. 61 to 0. There was no difference between the groups in cardiovascular mortality HR, 0.
98; 95 CI, 0. 82 to cheap Cerebramed. online 17. A renal event occurred in 4. 3 in the dapagliflozin group and 5. 6 in the placebo group HR, 0. 76; 95 CI, 0. 67 to 0. 87, and Death from any cause occurred in 6. 2 and 6. 6, respectively HR, 0. 93; 95 CI, 0. 82 to 1. Finally, it was determined that diabetic ketoacidosis optipred more frequent with dapagliflozin than with placebo 0. 3 versus 0. 1, p 0. 02, as well as the rate of genital infections that led to discontinuation of the regimen or that serious adverse events were considered 0. 9 versus 0. 1, p 0. 001. Along these lines, healthy habits and periodic check-ups are the two great messages on which our preventive policy is based.
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