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A collaborative group led by specialists at the Dana-Farber Cancer Institute in Boston, United States, conducted a phase 3 trial to evaluate the efficacy and safety of TAS-102 in a global population of this type of patient. 800 individuals were randomly assigned, in a 21 ratio, to receive TAS-102 or placebo. The primary end point was overall survival. But now, the authors of the article have pointed out that recently analyzed virological, epidemiological and ecological data allow us to hypothesize that facial masking would also reduce the severity of the disease among people who become infected. This possibility is consistent with the classic theory that maintains that the severity of viral conditions is proportional to the viral inoculum received. It is now thought that in viral infections in cheap cardiosel online host immune responses can play a predominant pathogenic role, as is the case with SARS-CoV-2, high doses of viral inoculum can overwhelm and deregulate innate immune defenses, increasing severity.

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