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The risk of COPD increased with decreasing telomere length according to quartile p trend p 7 Г- 10-92 for GOLD, p 8 x 10-44 for FEV1FVC less than LLN, although such associations also decreased after adjustment. The unadjusted and adjusted risks for short versus long telomeres according to quartiles were 2. 06 95 CI 1. 91-2. 22 and 1. 15 95 CI 1. 06-01. 25 for GOLD and 1. 73 95 CI 1. 60-1. 88 and 1. 19 95 CI 01. 09 to 01. 30 for FEV1FVC under LLN, respectively. Per 1,000 base pairs of decline, the multivariable-adjusted risk was 1. 07 95 CI 1. 3 to 1. 10 for GOLD and 1. 07 95 CI 01. 03 to 01. 11 for FEV1FVC less than LLN.

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