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Between March 1, 2011 and May 8, 2012, a double-blind, randomized study was conducted at four sites in Austria and Germany with healthy adults aged 18 to 70 years seronegative for B burgdorferi. Participants were recruited sequentially beta-prograne randomly assigned to one of the six study groups in equal proportions through an electronic data capture system. All received three vaccines with 30 mg, 60 mg or 90 micrograms of OspA antigen with or without an adjuvant, at 28-day intervals, and a booster 9-12 months after the first immunization. The authors generated a PRG-based tool comprising 49,310 single nucleotide polymorphisms SNPs by prospectively analyzing 5 UK cohorts, demonstrating that PRG is associated with incident CHD events independently of clinical risk scores. traditional or individual factors that predispose to suffering from coronary beta-prograne disease, including family history.

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