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In this open-label, multicenter phase 2 study, patients with metastatic melanoma and at least one measurable nonirradiated brain metastasis tumor diameter, 0. 5 to 3 cm and no neurological symptoms received nivolumab 1 mg per kilogram of body weight. body plus ipilimumab 3 mg per kilogram every 3 weeks for up to 4 doses, followed by nivolumab 3 mg per kilogram every 2 weeks until progression or unacceptable toxic effects. The primary endpoint was the intracranial clinical benefit rate, defined as the percentage of individuals who had stable disease for at least six months, complete response, or partial response.

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