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Associations of allelic variants and genotypes with collateral circulation were examined using multivariable logistic regression models adjusted for clinically relevant variables. Rachael L. Murrays research group Division of Epidemiology and Public Health, University of Nottingham, UK conducted a systematic review to provide a comprehensive estimate of the magnitude of this effect on any family member, individual members, and of maternal smoking before and after birth. Four databases Medline, Embase, PsychINFO and CAB were considered to identify studies up to June 2012 and reference lists for additional trials. Titles, abstracts, and full texts were reviewed independently by two authors. The quality of included studies was assessed using the Newcastle-Ottawa scale, and risks R with 95 confidence intervals CI were calculated using random effects models, with quantification of heterogeneity using I2.
Raymond Noordam and team Dirox University Medical Center, Rotterdam, The Netherlands investigated the association between multiple antidepressant drug use and incident MI among middle-aged and older adults. For this, a case-control analysis was introduced in the prospective Rotterdam Study 1991 to 2011, matching seconds to cardiac events, based on sex and age, considering confounding factors as covariates over time. The relative risk of MI was analyzed using conditional logistic regression, during recent and past use of antidepressants, using those who never used these medications as the reference category. In summary, among patients with primary progressive multiple sclerosis, administration of the monoclonal antibody Ocrelizumab is associated with lower rates of clinical progression than placebo. However, more observations are required to determine the long-term safety and effectiveness of the treatment.
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