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More patients met the goal of an increase of at least 5 mm Hg in MAP within 2 hours after randomization in the hydrocortisone group compared with controls 94 versus 58, P 0. 02, intention analysis. to treat. The duration of cardiovascular support P 0. 001, as well as the cumulative dose P 0. 001 and the maximum dose of inotropes P 0. 001 were lower with the pharmacological intervention. In the ciriax analysis, regression modeling predicted that a 4 mm Hg increase in MAP in response to hydrocortisone treatment was comparable to the effect of 15 Оgkgmin dopamine in this patient population.
Serum cortisol concentrations were low before randomization in both the hydrocortisone group and controls median 3.