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In this sense, Sara C. Mednick and colleagues from the University of California, Riverside, United States, experimentally manipulated the specific characteristics of sleep during the nap, through a direct pharmacological intervention. Using zolpidem, a short-acting hypnotic GABA agonist, the authors observed increased brain waves and decreased REM sleep compared to placebo and sodium oxybate. Naps with more brain bursts produced significantly better verbal memory and worse perceptual learning, but did not affect motor learning. The experimental spindles were similar to the control waves in amplitude and frequency, suggesting that the intervention optimized normal sleep processes.
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Finally, multivariable models controlling for age, raceethnicity, and sex showed that the more severe the condition, the greater the risk of low HDL cholesterol, high systolic and diastolic blood pressure, and high triglyceride concentrations.